0000000000621189

AUTHOR

Anna Lo Bue

showing 4 related works from this author

Obstructive Sleep Apnea Is Associated with Liver Damage and Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease

2015

Background/Aims We assessed whether obstructive sleep apnea (OSA) and nocturnal hypoxemia are associated with severity of liver fibrosis and carotid atherosclerosis in patients with biopsy-proven NAFLD and low prevalence of morbid obesity. Secondary aim was to explore the association of OSA and hypoxemia with NASH and severity of liver pathological changes. Methods Consecutive patients (n = 126) with chronically elevated ALT and NAFLD underwent STOP-BANG questionnaire to estimate OSA risk and ultrasonographic carotid assessment. In patients accepting to perform cardiorespiratory polygraphy (PG, n = 50), OSA was defined as an apnea/hypopnea index ≥5. A carotid atherosclerotic plaque was defi…

AdultCarotid Artery DiseasesLiver CirrhosisMalemedicine.medical_specialtyBiopsylcsh:MedicinePolysomnographySeverity of Illness IndexGastroenterologyLiver Function TestsNon-alcoholic Fatty Liver DiseaseRisk FactorsSurveys and QuestionnairesInternal medicineSeverity of illnessPrevalencemedicineHumansHypoxialcsh:ScienceAgedNAFLD OSAS ATHEROSCLEROSISSleep Apnea ObstructiveMultidisciplinarymedicine.diagnostic_testbusiness.industrylcsh:RFatty liverApneaSleep apneaMiddle AgedAtherosclerosismedicine.diseasePlaque Atheroscleroticrespiratory tract diseases3. Good healthObstructive sleep apneaEndocrinologyFemalelcsh:Qmedicine.symptombusinessLiver function testsHypopneaResearch ArticlePLOS ONE
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Relaxin in Obstructive Sleep Apnea: Relationship with Blood Pressure and Inflammatory Mediators

2015

<b><i>Background:</i></b> Obstructive sleep apnea (OSA) is associated with nocturnal intermittent hypoxia, which may be responsible for increased circulating levels of vascular endothelial growth factor (VEGF) and inflammatory mediators, such as metalloproteinases (MMPs), and which contributes to the pathogenesis of systemic hypertension. Why some OSA patients remain normotensive is poorly understood. Relaxin-2, a pregnancy hormone, may sometimes circulate in men and could increase in hypoxic conditions. It exerts a vasodilatory activity and can modulate the release of molecules, such as MMPs and VEGF. <b><i>Objectives:</i></b> The objective o…

AdultMaleVascular Endothelial Growth Factor APulmonary and Respiratory Medicinemedicine.medical_specialtyAmbulatory blood pressurePolysomnographyBlood PressurePolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratorio030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineRelaxin · Obstructive sleep apnea · Metalloproteinase · Vascular endothelial growth factorInterquartile rangeInternal medicineRespiratory disturbance indexmedicineHumansHypoxiaInflammationSleep Apnea ObstructiveTissue Inhibitor of Metalloproteinase-2Tissue Inhibitor of Metalloproteinase-1medicine.diagnostic_testbusiness.industryRelaxinSleep apneaTissue Inhibitor of MetalloproteinasesIntermittent hypoxiaMiddle Agedmedicine.diseaseMatrix MetalloproteinasesObstructive sleep apneaEndocrinologyBlood pressureMatrix Metalloproteinase 9030228 respiratory systemHypertensionMatrix Metalloproteinase 2Inflammation MediatorsbusinessRespiration
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Blood pressure changes after automatic and fixed CPAP in obstructive sleep apnea. Relationship with nocturnal sympathetic activity.

2011

Treatment of obstructive sleep apnea (OSA) by continuous positive airway pressure (CPAP) usually causes a reduction in blood pressure (BP), but several factors may interfere with its effects. In addition, although a high sympathetic activity is considered a major contributor to increased BP in OSA, a relationship between changes in BP and in sympathetic nervous system activity after OSA treatment is uncertain. This study was undertaken to assess if, in OSA subjects under no pharmacologic treatment, treatment by CPAP applied at variable levels by an automatic device (APAP) may be followed by a BP reduction, and if that treatment is associated with parallel changes in BP and catecholamine exc…

AdultMaleSympathetic nervous systemSympathetic Nervous SystemAmbulatory blood pressurePhysiologymedicine.medical_treatmentambulatory blood pressure monitoring catecholaminesBlood PressureSettore MED/10 - Malattie Dell'Apparato RespiratorioNorepinephrineCatecholaminesInternal MedicinemedicineHumansContinuous positive airway pressureWakefulnessSleep Apnea ObstructiveContinuous Positive Airway Pressurebusiness.industrySleep apneaGeneral MedicineBlood Pressure Monitoring AmbulatoryMiddle Agedmedicine.diseaseCircadian RhythmNormetanephrinenervous system diseasesrespiratory tract diseasesObstructive sleep apneamedicine.anatomical_structureBlood pressureAnesthesiaAmbulatoryCatecholamineSleepbusinessmedicine.drug
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Excessive Daytime Sleepiness and Sleep Disorders in a Population of Patients with Epilepsy: a Case-Control Study

2016

Background and purpose There are several primary causes for excessive daytime sleepiness (EDS) and sleep disorders in patients with epilepsy. Up to now, studies in the literature report conflicting data in terms of both prevalence and aetiology. The aim of our study was therefore to evaluate the prevalence of EDS and some sleep disorders in a population of patients with epilepsy treated with no more than two antiepileptic drugs (AEDs). We also investigated the role of the depression of mood as a variable that can negatively affect EDS. Methods We prospectively and consecutively recruited 99 patients with a diagnosis of epilepsy, sleep disorders and EDS, belonging to the Centre for Epilepsy …

Pediatricsmedicine.medical_specialtyPopulationExcessive daytime sleepiness03 medical and health sciencesEpilepsy0302 clinical medicineSleep debtObstructive sleep apnoea syndromemedicineRestless legs syndromeGeneralized epilepsyeducationeducation.field_of_studyEpilepsyExcessive daytime sleepinessbusiness.industrySleep disordersmedicine.diseaseMood030228 respiratory systemMood disordersOriginal Articlemedicine.symptombusiness030217 neurology & neurosurgeryJournal of Epilepsy Research
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