0000000000622647
AUTHOR
Xavier Duran
A science piction implant : organ transplants in literarure
Long before the first successful transplants were performed on humans, some writers had wrote about them in fiction. In this article, we show some examples and explain how even seemingly crazy ideas were inspired by real experiments. Starting from the 1970s, when transplants had already been standardised, some narratives started to pose real problems such as the lack of donors. The works mentioned here show the importance of literature and its contributions to the ethical and social debate surrounding transplants. They can also spread those debates to many other sectors.
Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2
Abstract Objective The aim of the study was to investigate the relationship between germline variations as a prognosis biomarker in patients with advanced Non-Small-Cell-Lung-Cancer (NSCLC) subjected to first-line platinum-based treatment. Materials and Methods We carried out a two-stage genome-wide-association study in non-small-cell lung cancer patients with platinum-based chemotherapy in an exploratory sample of 181 NSCLC patients from Caucasian origin, followed by a validation on 356 NSCLC patients from the same ancestry (Valencia, Spain). Results We identified germline variants in SMYD2 as a prognostic factor for survival in patients with advanced NSCLC receiving chemotherapy. SMYD2 al…