0000000000624559
AUTHOR
Seungjoon Lee
showing 2 related works from this author
Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitab…
2019
Shank3, a postsynaptic scaffolding protein involved in regulating excitatory synapse assembly and function, has been implicated in several brain disorders, including autism spectrum disorders (ASD), Phelan-McDermid syndrome, schizophrenia, intellectual disability, and mania. Here we generated and characterized a Shank3 knock-in mouse line carrying the Q321R mutation (Shank3Q321R mice) identified in a human individual with ASD that affects the ankyrin repeat region (ARR) domain of the Shank3 protein. Homozygous Shank3Q321R/Q321R mice show a selective decrease in the level of Shank3a, an ARR-containing protein variant, but not other variants. CA1 pyramidal neurons in the Shank3Q321R/Q321R hip…
Enhanced nonlocal power corrections to theB¯→Xsγdecay rate
2007
A new class of enhanced nonperturbative corrections to the inclusive $\overline{B}\ensuremath{\rightarrow}{X}_{s}\ensuremath{\gamma}$ decay rate is identified, which contribute first at order $\ensuremath{\Lambda}/{m}_{b}$ in the heavy-quark expansion and cannot be described using a local operator product expansion. Instead, these effects are described in terms of hadronic matrix elements of nonlocal operators with component fields separated by lightlike distances. They contribute to the high-energy part of the photon-energy spectrum but do not reduce to local operators when an integral over energy is taken to obtain the total inclusive decay rate. The dominant corrections depend on the fla…