OASIS-HT: design of a pharmacogenomic dose-finding study.
Experimental evidence and observations in humans strongly support an interactive role of mutated α-adducin, sodium (Na+)/potassium (K+)-adenosine triphosphatase (ATPase) activity and endogenous ouabain in Na+homeostasis and the pathogenesis of hypertension. The Ouabain and Adducin for Specific Intervention on Sodium in HyperTension (OASIS-HT) trial is an early Phase II dose-finding study, which will be conducted across 39 European centers. Following a run-in period of 4 weeks without treatment, eligible patients will be randomized to one of five oral doses of rostafuroxin consisting of 0.05, 0.15, 0.5, 1.5, or 5.0 mg/day. Each dose will be compared to a placebo in a double-blind crossover e…
Review of thermal infrared applications and requirements for future high-resolution sensors
High-resolution thermal infrared (TIR) remote sensing has a wide range of applications. In this paper, we describe the different applications and requirements identified in a literature review and during a consultation meeting with researcher experts in different fields. As a result, more than 30 applications were identified within three different fields: 1) land and solid Earth; 2) health and hazards; and 3) security and surveillance. A complete set of requirements (spatial, temporal, and radiometric resolution, algorithms used, and supporting data, among others) for each application is also provided. The results presented in this paper provide useful information to enhance the importance …
Review of High Resolution Thermal Infrared Applications and Requirements: The Fuegosat Synthesis Study
High resolution thermal infrared remote sensing can have a wide range of applications. In this chapter we describe the different applications and requirements identified after a revision study in the framework of the Fuegosat Synthesis Study (FSS). This project was funded by the European Space Agency (ESA), and the three main objectives were: (i) review of applications and analyses for user requirements, (ii) consolidation of user requirements over a broad range of applications, and (iii) matching of user requirements and industry concepts to identify and outline a set of potential mission scenarios and their corresponding requirements. This chapter focuses on issues (i) and (ii). These obj…