0000000000625376

AUTHOR

Karen Kapur

showing 2 related works from this author

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

2019

This work explores quantitative chromatin accessibility, transcriptional and cis-acting gene regulatory variations underlying mouse strain–specific differences in drug-induced liver tumor promotion sensitivity.

Male0301 basic medicine63Health Toxicology and MutagenesisGene regulatory networkPlant ScienceSMADBiologyBiochemistry Genetics and Molecular Biology (miscellaneous)Epigenesis GeneticMice03 medical and health sciences0302 clinical medicinemedicineAnimalsHumansGene Regulatory NetworksEpigeneticsWnt Signaling PathwayTranscription factorResearch ArticlesEcologyGene Expression ProfilingLiver NeoplasmsWnt signaling pathwayComputational Biology11Chromatin Assembly and Disassemblymedicine.diseaseChromatin3. Good healthChromatin030104 developmental biologyPhenobarbital030220 oncology & carcinogenesisCancer researchTumor promotionLiver cancerResearch ArticleLife Science Alliance
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Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis

2012

Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, relatively little is known about their underlying genetic determinants. Through transethnic meta-analysis of European-ancestry and Japanese genome-wide association studies, we identified six loci at genome-wide significance (p −8 ) for serum albumin ( HPN-SCN1B , GCKR-FNDC4 , SERPINF2-WDR81 , TNFRSF11A-ZCCHC2 , FRMD5-WDR76 , and RPS11-FCGRT , in up to 53,190 European-ancestry and 9,380 Japanese individuals) and three loci for total protein ( TNFRS13B , 6q21.3, and ELL2 , in …

MaleLinkage disequilibriumGenome-wide association studyDETERMINANTSLinkage DisequilibriumMiceGenetics(clinical)POPULATIONGenetics (clinical)SNPSRISKGeneticseducation.field_of_studybiologyChromosome MappingBlood ProteinsIDENTIFYMiddle AgedFemaleAdultPopulationSerum albuminserum protein; albumin; GWASSingle-nucleotide polymorphismLocus (genetics)ALBUMINWhite PeopleAsian PeopleGene mappingSDG 3 - Good Health and Well-beingReportBIOCHEMICAL TRAITSFC-RECEPTORGeneticsAnimalsHumansGenetic Predisposition to DiseaseSMOKING-BEHAVIORddc:610GENOME-WIDE ASSOCIATIONeducationAllelesSerum AlbuminAgedGenetic associationGenetic LociProtein BiosynthesisProteolysisbiology.proteinRibosomesGenome-Wide Association StudyThe American Journal of Human Genetics
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