0000000000626032

AUTHOR

Borghi C

showing 3 related works from this author

Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project

2021

Abstract Background Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on the mechanisms underlying the excess of cardiovascular mortality associated with both chronic kidney disease and hyperuricemia and lead to better risk stratification. Our main goal was to study the relationships between serum uric acid and kidney disease measures (namely estimated GFR [eGFR] and albuminuria) in a large cohort of individuals at cardiovascular risk from the URic acid Right for heArt Health (URRAH) Project database. Methods Clinica…

NephrologyAdultMalemedicine.medical_specialtySettore MED/09 - Medicina Interna030232 urology & nephrologyAllopurinolRenal functionHyperuricemia030204 cardiovascular system & hematologyKidneyurologic and male genital diseasesGastroenterology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineSerum uric acidRisk FactorsInternal medicineDiabetes mellitusmedicineeGFRHumansAlbuminuriaHyperuricemiaRenal Insufficiency ChronicAgedbusiness.industryAlbuminuria; Cardiovascular risk; Serum uric acid; eGFRnutritional and metabolic diseaseseGFR.Middle Agedmedicine.diseaseCardiovascular riskUric AcidchemistryNephrologyAlbuminuriaUric acidAlbuminuria; Cardiovascular risk; eGFR; Serum uric acidOriginal ArticleFemalemedicine.symptombusinessmedicine.drugKidney diseaseGlomerular Filtration Rate
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Ambulatory blood pressure and arterial stiffness web-based telemonitoring in patients at cardiovascular risk. First results of the VASOTENS (Vascular…

2019

The VASOTENS Registry is an international telehealth-based repository of 24-hour ambulatory blood pressure monitorings (ABPM) obtained through an oscillometric upper-arm BP monitor allowing combined estimation of some vascular biomarkers. The present paper reports the results obtained in 1200 participants according to different categories of CV risk. Individual readings were averaged for each recording and 24-hour mean of brachial and aortic systolic (SBP) and diastolic blood pressure (DBP), pulse wave velocity (PWV), and augmentation index (AIx) obtained. Peripheral and central BP, PWV and AIx values were increased in older participants (SBP only) and in case of hypertension (SBP and DBP).…

Malecentral aortic pressureNon-Randomized Controlled Trials as TopicEndocrinology Diabetes and Metabolism030204 cardiovascular system & hematologyaugmentation index0302 clinical medicinearterial stiffness; augmentation index; blood pressure; blood pressure telemonitoring; central aortic pressure; hypertension; pulse wave velocity; vascular biomarkersDiastoleRisk Factorsarterial stiffneProspective StudiesRegistries030212 general & internal medicinePulse wave velocityAortaMetabolic Syndromeblood pressureBlood Pressure Monitoring AmbulatoryMiddle AgedTelemedicinearterial stiffnessCardiovascular DiseasesAmbulatorycardiovascular systemCardiologyFemaleCardiology and Cardiovascular MedicineInternet-Based Interventioncirculatory and respiratory physiologyAdultmedicine.medical_specialtyAmbulatory blood pressurehypertensionSystolepulse wave velocityPulse Wave AnalysisVascular health03 medical and health sciencesVascular StiffnessOscillometryInternal medicineInternal MedicinemedicineHumansArterial PressureIn patientcardiovascular diseasesAgedblood pressure telemonitoringbusiness.industryvascular biomarkersmedicine.diseasevascular biomarkerCross-Sectional StudiesBlood pressureCase-Control StudiesArterial stiffnessMetabolic syndromebusiness
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The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk

2021

Abstract Introduction Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis. Aim We assessed the prognostic role of SUA in patients with and without MS. Methods We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure. Results A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previousl…

Malemedicine.medical_specialtySettore MED/09 - Medicina InternaCardiovascular mortalityPrognosiSudden cardiac deathchemistry.chemical_compoundSerum uric acidRisk FactorsInternal medicineCause of DeathmedicineHumansSerum uric acid.Myocardial infarctionCardiovascular mortality; Metabolic syndrome; Prognosis; Serum uric acidStrokeRetrospective StudiesOriginal Paperbusiness.industryProportional hazards modelHazard ratioGeneral MedicineMiddle Agedmedicine.diseasePrognosisMetabolic syndromeUric AcidSurvival RatechemistryItalyCardiovascular DiseasesHeart failureCardiologyUric acidFemaleMetabolic syndromeCardiology and Cardiovascular MedicinebusinessBiomarkersFollow-Up Studies
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