0000000000627033
AUTHOR
C. Scialabba
Inulin for Cancer Therapy: Present and Perspectives
Inulin is an extremely adaptable polysaccharides consisting of glucopyranose end-capped (β-1,2) fructose repeating units and, as it is, can be classified as an inherently multifunctional polymeric scaffold. It may be further functionalized employing mild conditions to give rise desired biological and physicochemical properties exploitable for targeted anticancer applications (e.g., active targeting toward specific cytotypes, self-assembling behavior, selective cytoxicity and hyperthermia features). In this review, the main chemical features and the inulin derivatives applications in the field of targeted anticancer therapy is reported and discussed
Electrospun Plasma-assisted Functionalized Ocular Inserts for Triamcinolone Acetonide Delivery
Topically administered ocular Drug Delivery Systems are the most desirable formulations for the treatment of ocular chronic diseases, being the most simple, convenient and patient-friendly ocular route of administration, despite it requires prolonged and continuous treatment over time. At this regard, ocular insert represent an innovative and effective strategy. Ocular inserts are solid/semisolid sterile preparations characterized by dimensions and shape specifically designed for topical ocular administration. They are able to rapidly adhere on the ocular surface and remain in situ for prolonged period while assuring a controlled drug release and potentially increasing drug transcorneal abs…
Smart inulin-based polycationic nanodevices for siRNA delivery
The advances of short interfering RNA (siRNA) mediated therapy provide a powerful option for the treatment of many diseases by silencing the expression of targeted genes including cancer development and progression. Inulin is a very simple and biocompatible polysaccharide proposed by our groups to produce interesting delivery systems for Nucleic Acid Based Drugs (NABDs), such as siRNA, either as polycations able to give polyplexes and polymeric coatings for nanosystems having a metallic core. In this research field, different functionalizing groups were linked to the inulin backbone with specific aims including oligoamine such as Ethylendiammine (EDA), Diethylediamine (DETA), Spermine, (SPM…