6533b834fe1ef96bd129e051
RESEARCH PRODUCT
Smart inulin-based polycationic nanodevices for siRNA delivery
Gaetano LambertiG. CavallaroC. SardoC. ScialabbaM. LicciardiG. Giammonasubject
3003Small interfering RNABiocompatibilitysiRNA complexing abilityInulinPharmaceutical ScienceSpermineNanotechnology02 engineering and technology010402 general chemistry01 natural scienceschemistry.chemical_compoundDrug Delivery SystemsPolyaminesBiocompatibility; Silencing ability; siRNA complexing ability; 3003HumansNanotechnologyGene silencingRNA Small InterferingChemistryInulin021001 nanoscience & nanotechnologyPolyelectrolytes0104 chemical sciencesBiochemistryNucleic acidBiocompatibilityCancer development0210 nano-technologySilencing abilityChemical designdescription
The advances of short interfering RNA (siRNA) mediated therapy provide a powerful option for the treatment of many diseases by silencing the expression of targeted genes including cancer development and progression. Inulin is a very simple and biocompatible polysaccharide proposed by our groups to produce interesting delivery systems for Nucleic Acid Based Drugs (NABDs), such as siRNA, either as polycations able to give polyplexes and polymeric coatings for nanosystems having a metallic core. In this research field, different functionalizing groups were linked to the inulin backbone with specific aims including oligoamine such as Ethylendiammine (EDA), Diethylediamine (DETA), Spermine, (SPM) etc. In this contribution the main Inulin-based nanodevices for the delivery of siRNA have been reported, analysed and compared with particular reference to their chemical design and structure, biocompatibility, siRNA complexing ability, silencing ability.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |