0000000000628010
AUTHOR
Oscar Arias
Dual-sided Mapping During Global Stretch Using a Custom Miniaturized Endocardial Balloon with a Multipurpose Multichannel Acquisition System for Preclinical Electrophysiological Studies
Acute regional myocardial stretch (STR) is known to induce myocardial electrophysiological modifications via mechano-electric feedback (MEF), including abnormal repolarization, premature excitation and increased complexity of activation leading to the initiation, maintenance and acceleration of arrhythmic events. Due to technical limitations little is known about intramural and endo-epicardial (ENDO-EPI) phenomena during these events. Understanding ENDO-EPI modifications produced by STR through MEF may require a dual-sided approach to simultaneously correlate macroscopic surface modifications and their independent or interconnected components. For that purpose, we optically mapped (OM) the …
A Single-sensor High-resolution Panoramic Optical Mapping Configuration for Simultaneous Non-overlapped Complete Atrial and Ventricular Parametric Imaging
Nowadays optical mapping (OM) is the primary method for imaging electrophysiologically relevant parameters from the outer surface of Langendorff-perfused hearts. This technique has become essential for comprehensively understanding mechanisms of cardiac propagation during physiological activation, arrhythmia, and therapeutic antiarrhythmic interventions in translational hearts. Panoramic whole heart optical mapping systems, using either multiple cameras, plane mirrors or a combination of both, have been developed to overcome intrinsic visualization limitations to traditional single-sensor designs. However current panoramic OM systems are financially challenging for physiology and engineerin…