0000000000631464

AUTHOR

Francesca Rajata

showing 2 related works from this author

MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma

2016

Hypoxia is a common feature in solid tumours. In glioma, it is considered the major driving force for tumour angiogenesis and correlates with enhanced resistance to conventional therapies, increased invasiveness and a poor prognosis for patients. Here we describe, for the first time, that miR675-5p, embedded in hypoxia-induced long non-coding RNA H19, plays a mandatory role in establishing a hypoxic response and in promoting hypoxia-mediated angiogenesis. We demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depletion in low oxygen conditions, drastically abolishes hypoxic responses including angiogenesis. In …

0301 basic medicinemiRNA675AngiogenesisMedicine (miscellaneous)RNA-binding proteinAngiogenesis; Glioma; HuR; Hypoxia; miRNA675; Optical imaging; VHL; Medicine (miscellaneous); Pharmacology Toxicology and Pharmaceutics (miscellaneous)BiologyToxicology and Pharmaceutics (miscellaneous)Cell LineELAV-Like Protein 1Miceoptical imaging03 medical and health sciencesSettore BIO/13 - Biologia ApplicataStress PhysiologicalIn vivoVHLGliomamicroRNAmedicineAnimalsHumansPharmacology Toxicology and Pharmaceutics (miscellaneous)PharmacologyAngiogenesis; HuR; VHL.; glioma; hypoxia; miRNA675; optical imagingMessenger RNANeovascularization PathologichypoxiaVHL.RNAGliomaHypoxia (medical)Hypoxia-Inducible Factor 1 alpha Subunitmedicine.disease3. Good healthAngiogenesiMicroRNAs030104 developmental biologyImmunologyCancer researchHeterograftsHuRAngiogenesismedicine.symptomResearch PaperTheranostics
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MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells

2017

// Viviana Costa 1, * , Alessia Lo Dico 2, * , Aroldo Rizzo 3 , Francesca Rajata 3 , Marco Tripodi 4, 5 , Riccardo Alessandro 6, 7, * , Alice Conigliaro 4, * 1 Innovative Technological Platforms for Tissue Engineering, Theranostic and Oncology, Rizzoli Orthopedic Institute, Palermo, Italy 2 Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milano, Italy 3 Unita Operativa di Anatomia Patologica, Azienda Ospedaliera Ospedali Riuniti “Villa Sofia-Cervello”, Palermo, Italy 4 Dipartimento di Biotecnologie Cellulari ed Ematologia, Sapienza University of Rome, Rome, Italy 5 National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy 6 Dipartimen…

0301 basic medicinePathologymedicine.medical_specialtymiRNA675Epithelial-Mesenchymal TransitionTranscription GeneticColorectal cancerDown-RegulationMetastasiMetastasis03 medical and health sciences0302 clinical medicineGliomaCell Line TumormedicinemetastasisHumansEpithelial–mesenchymal transitionNeoplasm MetastasisLymph nodeMetastatic colon cancerCRC; EMT; Hypoxia; Metastasis; MiRNA675; Oncologybusiness.industryhypoxiaEMTHypoxia (medical)medicine.diseaseHypoxia-Inducible Factor 1 alpha SubunitCell HypoxiaCRCTransplantationDNA-Binding ProteinsMicroRNAs030104 developmental biologymedicine.anatomical_structureOncology030220 oncology & carcinogenesisColonic NeoplasmsCancer researchmedicine.symptombusinessResearch Paper
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