0000000000631516

AUTHOR

Jacques Bara

showing 2 related works from this author

Blood group related antigens in ocular cicatricial pemphigoid

2004

Aim: To study the MUC5AC and the blood group related antigen expression in ocular cicatricial pemphigoid (OCP) according to the distribution of Lewis and secretor phenotypes in OCP patients compared to normal subjects. Methods: Immunostaining was performed on conjunctival biopsy specimens from 22 consecutive patients suffering from OCP, using monoclonal antibodies (Mabs) directed against the peptidic core MUC5AC mucin (anti-M1/MUC5AC Mabs) and against the saccharide moieties (anti-blood group related antigens). These latter included anti-Lea, anti-Leb, anti-sialyl Lea, and H type 2 Mabs, which immunoreact with Lewis positive and non-secretor (Lea), Lewis positive and secretor (Leb), Lewis p…

Adultmedicine.drug_classPopulationPemphigoid Benign Mucous MembraneClinical Science - Scientific ReportsMucin 5ACMonoclonal antibodyConjunctival DiseasesSerologyCellular and Molecular Neurosciencefluids and secretionsLewis Blood Group AntigensAntigenImmunopathologyMedicineHumans[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory OrganseducationAgedAutoimmune diseaseAged 80 and overeducation.field_of_studybusiness.industryMucinMucinsEpithelial CellsMiddle Agedmedicine.diseaseMucin-5BSensory Systemseye diseasesOphthalmologyPhenotypeImmunologyBlood Group Antigenssense organsGoblet Cellsbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyImmunostaining
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Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca

2000

Abstract Purpose To investigate by flow cytometry and impression cytology (IC) specimens the inflammatory status of the conjunctival epithelium and goblet cell density in two series of patients with rosacea and dry eye syndrome compared with a population of healthy subjects. Design Nonrandomized, prospective, comparative case series. Participants Twenty-six eyes of 13 patients with rosacea, 26 eyes of 13 patients with dry eye syndrome, and 24 eyes of 12 control subjects were included in this study. Methods IC specimens were collected after clinical examination of the ocular surface and analyzed by flow cytometry, using antibodies directed to human lymphocyte antigen-DR (HLA-DR), intercellul…

AdultMalePathologymedicine.medical_specialtyConjunctivaEye diseasePopulationKeratoconjunctivitis SiccaCell CountOcular rosaceaMucin 5ACConjunctival DiseasesEpitheliumKeratitisCytologymedicineHumansProspective StudieseducationAgedAged 80 and overGoblet celleducation.field_of_studybusiness.industryMucinsHLA-DR AntigensMiddle AgedFlow CytometryIntercellular Adhesion Molecule-1medicine.diseaseeye diseasesOphthalmologymedicine.anatomical_structureRosaceaTearsRosaceaEyelid DiseasesFemaleGoblet Cellssense organsbusinessConjunctivaOphthalmology
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