0000000000636386

AUTHOR

Sacha Kacki

showing 3 related works from this author

Ten millennia of hepatitis B virus evolution

2021

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd…

Phylogeographic historyHepatitis B/history01 natural sciencesThe RepublicCommunicable Diseases EmergingGermanCommunicable Diseases Emerging/historyAgency (sociology)Science and technologyComputingMilieux_MISCELLANEOUSHistory AncientPhylogenymedia_common0303 health sciencesMultidisciplinaryAncient DNAEuropean researchvirus diseasesGenomicsHepatitis B3. Good healthEuropelanguageComputingMethodologies_DOCUMENTANDTEXTPROCESSINGChristian ministryPaleogenomic analysesAsian Continental Ancestry Group010506 paleontologyHepatitis B virusAsiaHepatitis B virus/classificationEuropean Continental Ancestry GroupLibrary scienceBiología CelularWhite PeopleMarie curieEvolution Molecular03 medical and health sciencesAmerican NativesAsian PeoplePolitical scienceGenomic datamedia_common.cataloged_instanceHumansSlovakEuropean unionAmerican Indian or Alaska Native030304 developmental biology0105 earth and related environmental sciencesGenetic VariationPaleontologyPrehistoriaA300language.human_languagedigestive system diseasesAmerican natives; Americas; Asia; Asian continental ancestry group; Communicable diseases Emerging; Europe; European continental ancestry group; Evolution molecular; Genetic variation; Genomics; Hepatitis B; Hepatitis B virus; History Ancient; Humans; Paleontology; PhylogenyAmericas
researchProduct

Distinct Clones of Yersinia pestis Caused the Black Death

2010

From AD 1347 to AD 1353, the Black Death killed tens of millions of people in Europe, leaving misery and devastation in its wake, with successive epidemics ravaging the continent until the 18th century. The etiology of this disease has remained highly controversial, ranging from claims based on genetics and the historical descriptions of symptoms that it was caused by Yersinia pestis to conclusions that it must have been caused by other pathogens. It has also been disputed whether plague had the same etiology in northern and southern Europe. Here we identified DNA and protein signatures specific for Y. pestis in human skeletons from mass graves in northern, central and southern Europe that …

Yersinia pestis[SDV]Life Sciences [q-bio]Sequence HomologyDiseaseMESH: Base SequenceMESH: Genetic Markers[SHS]Humanities and Social SciencesDisease OutbreaksInfectious Diseases/Bacterial InfectionsMESH: GenotypeGenotypeMass ScreeningBiology (General)MESH: Disease OutbreaksMESH: PhylogenyCladePhylogenyGenetics0303 health sciencesMicrobiology/Microbial Evolution and GenomicsbiologyClones; Yersinia pestis; Black DeathBacterialGenetics and Genomics/Microbial Evolution and Genomics3. Good healthEuropeEvolutionary Biology/Human EvolutionInfectious DiseasesResearch ArticleDNA BacterialGenetic MarkersGenotypeQH301-705.5Molecular Sequence DataImmunologyMESH: Yersinia pestisZoologyMolecular Biology/Molecular EvolutionPlague (disease)MESH: PlagueMESH: Sequence Homology Nucleic AcidMicrobiologyNO03 medical and health sciencesPhylogeneticsSequence Homology Nucleic AcidVirologyGeneticsHumansMESH: Mass ScreeningEpidemicsMolecular BiologyMESH: EpidemicsMass screening030304 developmental biologyPlagueEvolutionary BiologyMESH: HumansMESH: Molecular Sequence DataNucleic AcidBase Sequence030306 microbiologyGenetics and GenomicsDNARC581-607biology.organism_classificationMESH: DNA BacterialYersinia pestisBase Sequence; DNA Bacterial; Disease Outbreaks; Epidemics; Europe; Genetic Markers; Genotype; Humans; Mass Screening; Molecular Sequence Data; Phylogeny; Plague; Sequence Homology Nucleic Acid; Yersinia pestisEtiologyParasitologyMESH: EuropeImmunologic diseases. Allergy
researchProduct

Lesquin (Nord), ZAC du Mélantois, Au Chemin Perdu : la nécropole mérovingienne du hameau de Merchin (zone 2) (fin Ve siècle-début VIIIe siècle) : rap…

2015

La construction d'un complexe d'entreprises au hameau de Merchin, au sein d'une zone sensible de découvertes archéologiques, a motivé plusieurs prescriptions de fouille qui se sont déroulées entre l'été 2008 et l'été 2009. Elles ont porté sur un ensemble de structures néolithiques, sur un complexe à vocation agro-pastoral protohistorique/antique, et, enfin, sur une nécropole du premier Moyen Âge. Inscrite dans un terroir occupé de manière plus ou moins continue depuis le Hallstatt jusqu'au bas Moyen Âge, la nécropole mérovingienne de Lesquin est localisée sur la frange orientale du plateau du Mélantois. Elle supplante une occupation débutée au Hallstatt au travers de l'élément structurant l…

[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and PrehistoryHallstatttombe sous tuilevoirieNéolithiqueverrerieLa Tèneexploitation des donnéesHaut-EmpireHaut Moyen Âgeincinérationinhumation[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistorytextileterroirplaque-bouclefoyerdrainarmeméthodologieparuremonnaie romaineTemps modernesnécropolevaisselle de métalépoque mérovingiennemonnaie mérovingiennetombe à chambreoccupation du sol
researchProduct