6533b7dafe1ef96bd126e3c0
RESEARCH PRODUCT
Ten millennia of hepatitis B virus evolution
Oleg BalanovskyLourdes Marquez-morfinMagdalena ZoledziewskaSusannah J. SalterCody E. ParkerCody E. ParkerKirsten I. BosKathrin NägeleDomingo C. Salazar-garcíaDomingo C. Salazar-garcíaDomingo C. Salazar-garcíaKerttu MajanderKerttu MajanderVittorio MazzarelloCosimo PosthCosimo PosthKurt W. AltKurt W. AltElmira KhussainovaSilvia Teresita Hernández GodoyRichard MortimerAyshin GhalichiAlexander HerbigLars Fehren-schmitzLeyla B. DjansugurovaDmitry A. StashenkovRaiko KraußMikhail S. ChaplyginTiago FerrazTiago FerrazPatrick SemalEva RosenstockMichal KostkaYavor BoyadzhievHarald MellerPetr LimburskýMario KüßnerTara IngmanMaïté RivollatMaïté RivollatEva Fernández-domínguezRodrigo BarqueraRobin SkeatesKamen BoyadzhievDenise KühnertMirjana RoksandicMirjana RoksandicAdam Ben RohrlachAdam Ben RohrlachAlexandra P. BuzhilovaAlissa MittnikAlissa MittnikYadira Chinique De ArmasJohannes KrauseMarie-france DeguillouxAleksandr KhokhlovRezeda I. TukhbatovaRezeda I. TukhbatovaElizabeth PopescuLucy C. SalazarAndrey A. ChizhevskyChristopher ReadHubert SteinerMelanie Van TwestEveline AltenaDiana Iraíz Hernández-zaragozaLyazzat MusralinaMegan MichelMegan MichelÍñIgo García-martínez De LagránAnatoly R. KantorovichKatrien Van De VijverKatrien Van De VijverAlžbeta DanielisováRachel ClarkeDuncan SayerBastien LlamasBastien LlamasNikolaj MakarovAlejandro RomeroLuka PapacAlessandra SperdutiVladimir E. MaslovRafael Garrido-penaGunnar U. NeumannArman Z. BeisenovZainolla SamashevGuido Alberto Gnecchi-rusconePäivi OnkamoPäivi OnkamoEduardo Carmona BallesteroJavier Jimenez-echevarriaValery KhartanovichManuel Rojo-guerraFredrik HallgrenEirini SkourtaniotiNatalia ShishlinaLuca LaiLuca LaiPetr VelemínskýAntti SajantilaPeter C. RamslClaudia SagonaSusanne FriederichMiroslav DobešMarcel KellerMarcel KellerFrancesco CuccaSabine ReinholdFlorian Van BömmelLuc AmkreutzVittoria SchimmentiRaphaela StahlDouglas BairdMarina K. KarapetianKurt RademakerStephan SchiffelsSacha KackiSacha KackiEvelyn K. GuevaraEvelyn K. GuevaraMichael FranckenChristina WarinnerChristina WarinnerKay PrüferKaren GiffinFelix M. KeyJoscha GretzingerAlexey KalmykovSvetlana ShnaiderSandra PenskeAntje WissgottTiffiny A. TungBiaslan Ch. AtabievPhilippe LefrancElizabeth A. NelsonPeter De KnijffVladimir SlavchevJessica PearsonYılmaz Selim ErdalLouise LoeJan NováčekMicaela Alvarez CalmetJosé I. Royo-guillénRichard L. BurgerKristiina MannermaaK. Aslıhan YenerMaria PfefferkornVyacheslav MoiseyevSvend HansenDidier BinderMichal ErnéeMaria A. SpyrouMaria A. SpyrouMichal FeldmanMichal FeldmanVladimir V. KufterinMurat AkarHéctor Arcusa-magallónAndrej B. BelinskiyEgor KitovFranziska AronRon HüblerVanessa Villalba-moucoVanessa Villalba-moucoSophie BeckettSophie BeckettJessica BeckettArthur KocherMichael SchultzElena BatievaPilar UtrillaCristina Tejedor-rodríguezKristin Von HeykingMasnav NavruzbekovMichaela LangováMaria Paz Miguel De IbáñezStéphane RottierMaria V. DobrovolskayaSandra LöschEmma D. ZilivinskayaDmitry V. VasilevGabriel García AtiénzarMarcello A. ManninoMarcello A. ManninoWolfgang HaakWolfgang HaakPhilipp W. StockhammerPhilipp W. StockhammerSylvie SaintotAlice LyonsKen MassyElena KaverznevaSusanna SabinCarmen Alonso-fernándezAnna F. KochkinaMarieke Sophia Van De LoosdrechtStefanie Eisenmannsubject
Phylogeographic historyHepatitis B/history01 natural sciencesThe RepublicCommunicable Diseases EmergingGermanCommunicable Diseases Emerging/historyAgency (sociology)Science and technologyComputingMilieux_MISCELLANEOUSHistory AncientPhylogenymedia_common0303 health sciencesMultidisciplinaryAncient DNAEuropean researchvirus diseasesGenomicsHepatitis B3. Good healthEuropelanguageComputingMethodologies_DOCUMENTANDTEXTPROCESSINGChristian ministryPaleogenomic analysesAsian Continental Ancestry Group010506 paleontologyHepatitis B virusAsiaHepatitis B virus/classificationEuropean Continental Ancestry GroupLibrary scienceBiología CelularWhite PeopleMarie curieEvolution Molecular03 medical and health sciencesAmerican NativesAsian PeoplePolitical scienceGenomic datamedia_common.cataloged_instanceHumansSlovakEuropean unionAmerican Indian or Alaska Native030304 developmental biology0105 earth and related environmental sciencesGenetic VariationPaleontologyPrehistoriaA300language.human_languagedigestive system diseasesAmerican natives; Americas; Asia; Asian continental ancestry group; Communicable diseases Emerging; Europe; European continental ancestry group; Evolution molecular; Genetic variation; Genomics; Hepatitis B; Hepatitis B virus; History Ancient; Humans; Paleontology; PhylogenyAmericasdescription
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-10-08 |