0000000000639708

AUTHOR

H. R. Julien

showing 2 related works from this author

Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids fromDiospyros leucomelas*

1995

Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.

medicine.drug_classAnti-Inflammatory AgentsPharmaceutical ScienceBiologyPharmacognosyPharmacologyAnti-inflammatoryAnalytical ChemistryMicechemistry.chemical_compoundTriterpeneUrsolic acidBetulinic acidDrug DiscoverymedicineAnimalsBetulinic AcidPharmacologychemistry.chemical_classificationPlants MedicinalBetulinOrganic ChemistryTriterpenesCarrageenanComplementary and alternative medicinechemistryBiochemistryMechanism of actionMolecular MedicineFemaleSteroidsmedicine.symptomPentacyclic TriterpenesPlanta Medica
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Anti-Inflammatory Activity of Flavonol Glycosides fromErythrospermum monticolumDepending on Single or Repeated Local TPA Administration

1995

Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-->2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.

medicine.drug_classFlavonoidPharmaceutical SciencePharmacologyPharmacognosyDisaccharidesAnti-inflammatoryAnalytical Chemistrylaw.inventionMicechemistry.chemical_compoundFlacourtiaceaelawDrug DiscoverymedicineAnimalsEdemaBioassayheterocyclic compoundsPharmacologychemistry.chemical_classificationbiologyAnti-Inflammatory Agents Non-SteroidalOrganic ChemistryGlycosidebiology.organism_classificationComplementary and alternative medicinechemistryBiochemistryTetradecanoylphorbol AcetateMolecular MedicineFemaleQuercetinPhytotherapyQuercetinPlanta Medica
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