6533b838fe1ef96bd12a3c76
RESEARCH PRODUCT
Anti-Inflammatory Activity of Flavonol Glycosides fromErythrospermum monticolumDepending on Single or Repeated Local TPA Administration
Laura CubellsJosé-luis RíosS. MáñezMaría Del Carmen RecioKurt HostettmannJoseph GuehoAmparo TalensRosa M. GinerH. R. Juliensubject
medicine.drug_classFlavonoidPharmaceutical SciencePharmacologyPharmacognosyDisaccharidesAnti-inflammatoryAnalytical Chemistrylaw.inventionMicechemistry.chemical_compoundFlacourtiaceaelawDrug DiscoverymedicineAnimalsEdemaBioassayheterocyclic compoundsPharmacologychemistry.chemical_classificationbiologyAnti-Inflammatory Agents Non-SteroidalOrganic ChemistryGlycosidebiology.organism_classificationComplementary and alternative medicinechemistryBiochemistryTetradecanoylphorbol AcetateMolecular MedicineFemaleQuercetinPhytotherapyQuercetindescription
Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-->2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-12-01 | Planta Medica |