0000000000642699

AUTHOR

D. Moro

showing 3 related works from this author

E-Cadherin-beta-catenin adhesion complex in neuroendocrine tumors of the lung : asuggested role upon local invasion and metastasis

2004

International audience

[SDV] Life Sciences [q-bio][SDE] Environmental SciencesE-CATHERINE[SDV]Life Sciences [q-bio][SDE]Environmental SciencesCANCERComputingMilieux_MISCELLANEOUSBETA-CATENINE
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Effect of a 3-week body mass reduction program on body composition, muscle function and motor performance in pubertal obese boys and girls

2005

The aim of this study was to investigate the effects of a multidisciplinary body mass reduction (BMR) program on body composition, muscle function and motor performance in 50 obese [mean body mass index (BMI): 35.9+/-5.8 kg/m2] boys and girls aged 12-17 yr (Tanner stage III, IV and V). The hospital-based BMR program combined an energy-restricted diet (1400-1600 kcal), nutritional education, psychological counselling and moderate physical activity (45-60 min/ session; 5 sessions/week; 60-80% of the maximal heart rate) during a 3-week period. Fat mass, fat-free mass, maximal power during jumping and stair climbing as well as maximal strength of the upper and lower limb muscles were quantified…

CounselingMalemedicine.medical_specialtyAdolescentDiet ReducingNutritional SciencesMass reductionMovementEndocrinology Diabetes and MetabolismPhysical exercisemedicine.disease_causeFat massVertical jumpEndocrinologyJumpingPatient Education as TopicInternal medicineHeart ratemedicineHumansObesityMuscle SkeletalExerciseCaloric Restrictionbusiness.industryStair climbingPubertyTreatment OutcomeEndocrinologyBody CompositionFemalebusinessBody mass indexJournal of Endocrinological Investigation
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Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.

2019

A high percentage of patients diagnosed with localized colon cancer (CC) will relapse after curative treatment. Although pathological staging currently guides our treatment decisions, there are no biomarkers determining minimal residual disease (MRD) and patients are at risk of being undertreated or even overtreated with chemotherapy in this setting. Circulating-tumor DNA (ctDNA) can to be a useful tool to better detect risk of relapse.One hundred and fifty patients diagnosed with localized CC were prospectively enrolled in our study. Tumor tissue from those patients was sequenced by a custom-targeted next-generation sequencing (NGS) panel to characterize somatic mutations. A minimum varian…

0301 basic medicineOncologyMalemedicine.medical_specialtyNeoplasm ResidualColorectal cancerColonmedicine.medical_treatmentPathological stagingConcordanceDNA Mutational AnalysisKaplan-Meier EstimateAdenocarcinomaDisease-Free Survivallaw.inventionCirculating Tumor DNA03 medical and health sciences0302 clinical medicineGene FrequencylawInternal medicineBiomarkers TumorMedicineHumansDigital polymerase chain reactionPostoperative PeriodProspective StudiesPolymerase chain reactionColectomyAgedChemotherapybusiness.industryHazard ratioHigh-Throughput Nucleotide SequencingHematologymedicine.diseaseMinimal residual disease030104 developmental biologyOncology030220 oncology & carcinogenesisColonic NeoplasmsMutationFemaleNeoplasm Recurrence LocalbusinessFollow-Up StudiesAnnals of oncology : official journal of the European Society for Medical Oncology
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