0000000000644322
AUTHOR
Jaume Aguero
Changes in Adrenoceptor and GRK Expression in Patients With Chronic Pulmonary Regurgitation.
INTRODUCTION AND OBJECTIVES Pulmonary regurgitation (PR) is a frequent complication after repair of congenital heart disease. Lymphocyte expression of adrenoceptors (β1 and β2) and kinases (GRK2, GRK3, and GRK5) reflects the neurohumoral changes that occur in heart failure (HF). The main objective of this study was to describe the gene expression of these molecules in circulating lymphocytes in patients with severe PR. METHODS A prospective study was conducted to analyze lymphocyte expression of these molecules in patients with severe PR and compare it with expression in healthy controls and patients with advanced HF. RESULTS We studied 35 patients with severe PR, 22 healthy controls, and 1…
Left ventricular ejection fraction recovery in patients with heart failure treated with intravenous iron: a pilot study
Aims In patients with heart failure with reduced ejection fraction (HFrEF) and iron deficiency, treatment with intravenous iron has shown a clinical improvement regardless of anaemic status. Cardiac magnetic resonance (CMR) T2* sequence has shown a potential utility for evaluating myocardial iron deficiency. We aimed to evaluate whether T2* sequence significantly changes after ferric carboximaltose (FCM) administration, and if such changes correlate with changes in left ventricle ejection fraction (LVEF). Methods and results In this pilot study, we included eight patients with chronic symptomatic (New York Heart Association II–III) HFrEF and iron deficiency. A CMR, including T2* analysis, w…
Cambios en la expresión de adrenoceptores y GRK en pacientes con insuficiencia pulmonar valvular crónica
Resumen Introduccion y objetivos La insuficiencia pulmonar (IP) es una complicacion frecuente tras la intervencion de cardiopatias congenitas. La expresion en leucocitos mononucleares circulantes (LMC) de los adrenoceptores (β1 y β2) y de las cinasas (GRK2, GRK3 y GRK5) refleja los cambios neurohumorales que se producen en la insuficiencia cardiaca (IC). El objetivo principal es describir la expresion genica de dichas moleculas en LMC de pacientes con IP grave. Metodos Estudio prospectivo que analizo la expresion de las moleculas descritas en LMC de pacientes con IP grave en comparacion con controles sanos y pacientes con IC avanzada. Resultados Se estudio a 35 pacientes con IP grave, 22 co…