0000000000644469

AUTHOR

Meike Mertens

showing 4 related works from this author

Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

2019

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone. peerReviewed

synthesispatogeneesiGeneral Chemical EngineeringDegeneration (medical)010402 general chemistry01 natural sciencesneurokemialcsh:ChemistryPathogenesis03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicinecharacterizationsynteesita116water-soluble cuprizone derivativekemiallinen synteesiin Vitro studiesamiinitChemistryta1182General ChemistryOligodendrocyteIn vitro3. Good health0104 chemical sciencesmedicine.anatomical_structureWater solublelcsh:QD1-999Biochemistryin vitro -menetelmä030217 neurology & neurosurgeryDerivative (chemistry)
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CCDC 1846187: Experimental Crystal Structure Determination

2019

Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN'1N'2-bis(1-methylpiperidin-4-ylidene)ethanedihydrazideExperimental 3D Coordinates
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CCDC 1846185: Experimental Crystal Structure Determination

2019

Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters811-dimethyl-781112-tetraazaspiro[5.6]dodecane-910-dioneExperimental 3D Coordinates
researchProduct

CCDC 1846186: Experimental Crystal Structure Determination

2019

Related Article: Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, and Tim Clarner|2019|ACS Omega|4|1685|doi:10.1021/acsomega.8b02523

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN'1N'2-dicycloheptylideneethanedihydrazideExperimental 3D Coordinates
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