6533b829fe1ef96bd128996c
RESEARCH PRODUCT
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies
Kari RissanenMarkus KippArto ValkonenCordian BeyerMeike MertensThomas WillmsNico TeskeMartin FriesTim ClarnerMarkus Albrechtsubject
synthesispatogeneesiGeneral Chemical EngineeringDegeneration (medical)010402 general chemistry01 natural sciencesneurokemialcsh:ChemistryPathogenesis03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicinecharacterizationsynteesita116water-soluble cuprizone derivativekemiallinen synteesiin Vitro studiesamiinitChemistryta1182General ChemistryOligodendrocyteIn vitro3. Good health0104 chemical sciencesmedicine.anatomical_structureWater solublelcsh:QD1-999Biochemistryin vitro -menetelmä030217 neurology & neurosurgeryDerivative (chemistry)description
The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-18 |