Author: Amparo Ortiz

0000000000650387

AUTHOR

Amparo Ortiz

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Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECT in Guinea Pig: Role of Bitter Taste Agonists

2016

Different image techniques have been used to analyze mucociliary clearance (MCC) in humans, but current small animal MCC analysis using in vivo imaging has not been well defined. Bitter taste receptor (T2R) agonists increase ciliary beat frequency (CBF) and cause bronchodilation but their effects in vivo are not well understood. This work analyzes in vivo nasal and bronchial MCC in guinea pig animals using three dimension (3D) microCT-SPECT images and evaluates the effect of T2R agonists. Intranasal macroaggreggates of albumin-Technetium 99 metastable (MAA-Tc99m) and lung nebulized Tc99m albumin nanocolloids were used to analyze the effect of T2R agonists on nasal and bronchial MCC respecti…

0301 basic medicinePathologyPhysiologyRespiratory Systemlcsh:MedicineSingle Photon Emission Computed TomographyPharmacologyBiochemistryDiagnostic RadiologyReceptors G-Protein-CoupledMathematical and Statistical Techniques0302 clinical medicineBronchodilationMedicine and Health Scienceslcsh:ScienceTomographyLungMammalsMultidisciplinaryRadiology and ImagingDrugsfood and beveragesChloroquineAnimal Modelsrespiratory systemPulmonary ImagingBody Fluidsmedicine.anatomical_structureMucociliary ClearanceVertebratesPhysical SciencesAnatomyStatistics (Mathematics)Research ArticleAgonistmedicine.medical_specialtySingle Photon Emission Computed Tomography Computed TomographyImaging TechniquesMucociliary clearancemedicine.drug_classGuinea PigsBronchiNeuroimagingResearch and Analysis MethodsRodentsGuinea pigAntimalarials03 medical and health sciencesModel OrganismsDiagnostic MedicineIn vivoAlbuminsmedicineAnimalsHumansStatistical MethodsPharmacologyAnalysis of VarianceLungbusiness.industrylcsh:ROrganismsBiology and Life SciencesProteinsX-Ray MicrotomographyMucus030104 developmental biology030228 respiratory systemAmniotesNanoparticleslcsh:QNasal administrationbusinessMathematicsEx vivoNeuroscience

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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