0000000000650504

AUTHOR

Bernhard Dichtl

showing 2 related works from this author

A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export.

2018

17 páginas, 12 figuras.

0301 basic medicineChromatin ImmunoprecipitationSaccharomyces cerevisiae ProteinsTranscription GeneticSaccharomyces cerevisiaeBiologyyeastEpigenetic RepressionBiochemistryRNA TransportHistones03 medical and health sciencesHistone H30302 clinical medicineTranscription (biology)Gene Expression Regulation FungalGeneticsHistone H2BMonoubiquitinationEpigeneticsRNA MessengerMolecular BiologyGenemRNA exportepigeneticsUbiquitinationMethylationArticlesTATA-Box Binding ProteinYeastCell biology030104 developmental biologyran GTP-Binding ProteinH3K4me3EpigeneticsRNA Polymerase IItranscriptionTranscription030217 neurology & neurosurgeryH2B ubiquitinationEMBO reports
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Protein Interactions within the Set1 Complex and Their Roles in the Regulation of Histone 3 Lysine 4 Methylation

2006

Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3K4). Here we have determined protein/protein interactions within the complex and related the substructure to function. The loss of individual Set1C subunits differentially affects Set1 stability, complex integrity, global H3K4 methylation, and distribution of H3K4 methylation along active genes. The complex requires Set1, Swd1, and Swd3 for integrity, and Set1 amount is greatly reduced in the absence of the Swd1-Swd3 heterodimer. Bre2 and Sdc1 also form a heteromeric subunit, which requires the SET domain for interaction with the complex, and Sdc…

Saccharomyces cerevisiae ProteinsProtein subunitLysineRNA polymerase IISaccharomyces cerevisiaeMethylationenvironment and public healthBiochemistryProtein–protein interactionHistonesSerineGene Expression Regulation FungalCoding regionMolecular BiologybiologyLysineHistone-Lysine N-MethyltransferaseCell BiologyMethylationDNA-Binding ProteinsProtein SubunitsHistoneBiochemistrybiology.proteinProtein BindingTranscription FactorsJournal of Biological Chemistry
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