Significance of magnesium in insulin resistance, metabolic syndrome, and diabetes – recommendations of the Association of Magnesium Research e.V.

Magnesium (Mg) depletion is an important and highly prevalent condition in patients with diabetes or precursor states of type-2 diabetes like metabolic syndrome. Mg deficiency increases the risk of developing type-2 diabetes. These recommendations compile present data on the physiology of Mg in carbohydrate metabolism and pathophysiological consequences of Mg depletion for diabetics. Diabetes patients and candidates benefit from four categories of Mg effects: insulin-sensitizing effect, calcium antagonism, stress-regulating and endotheli-um-stabilizing effects. Clinical data with Mg co-medication show improvement of insulin resistance/blood glucose level and reduced long-term vascular damag…