Die Bedeutung der Bindung von Pharmaka an Albumin und Erythrocyten eines Perfusionsmediums der isolierten Rattenleber

The binding of lipophilic drugs to albumin and erythrocytes and its importance for the uptake of the drugs into the isolated rat liver were investigated. Promazine and chlorpromazine were taken as lipophilic drugs, which were compared in some experiments with 3,3′-dimethyl-4,4′-diacetyldiphenylbisguanylhydrazone (BG 60), a much more hydrophilic drug.