showing 2 related works from this author
IRS-2 deficiency impairs NMDA receptor-dependent long-term potentiation
2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.-- et al.
Stressor-related impairment of synaptic transmission in hippocampal slices from α-synuclein knockout mice
2004
The role of alpha-synuclein (alpha-Syn) has recently received considerable attention because it seems to play a role in Parkinson's disease (PD). Missense mutations in the alpha-Syn gene were found in autosomal dominant PD and alpha-Syn was shown to be a major constituent of protein aggregates in sporadic PD and other synucleinopathies. Under normal conditions, alpha-Syn protein is found exclusively in synaptic terminals. However, the potential participation of alpha-synuclein in maintaining and regulating synaptic efficacy is unknown. We have investigated the excitatory synaptic modulation of alpha-synuclein in CA1 pyramidal neurons, using the in vitro hippocampal slice technique. The 4-am…