0000000000671798
AUTHOR
J. De Vente
Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg was investigated through 96 weeks in EMERALD (NCT02269917). Virologically-suppressed, HIV-1-positive treatment-experienced adults (previous non-darunavir virologic failure [VF] allowed) were randomized (2:1) to D/C/F/TAF or boosted protease inhibitor (PI) plus emtricitabine/tenofovir-disoproxil-fumarate (F/TDF) over 48 weeks. At week 52 participants in the boosted PI arm were offered switch to D/C/F/TAF (late-switch, 44 weeks D/C/F/TAF exposure). All participants were followed on D/C/F/TAF until week 96. Efficacy endpoints were percentage cumulative protocol-defined virologic rebound (PDVR; confirmed vira…
A review of runoff generation and soil erosion across scales in semiarid south-eastern Spain
Climate, lithology, soil and especially, intense land use/cover changes, make SE Spain very vulnerable to runoff generation and water erosion leading to loss of nutrients and organic matter and to infrequent but devastating floods, reservoir siltation and mass failures. This susceptibility has led to heavy economic investment and research efforts since the 1980s, making this region a worldwide reference for understanding the hydrology and geomorphology of semiarid ecosystems. Runoff and soil erosion have been intensively studied throughout the last decades in various natural ecosystems as well as in abandoned farmlands. Research has considered a wide range of methods and spatial and tempora…