Vaccinazioni: stato dell’arte, falsi miti e prospettive. Il ruolo chiave della prevenzione.

La pratica vaccinale in Italia è organizzativamente incardinata all’interno del Servizio Sanitario Nazionale (SSN) e nei Servizi Sanitari Regionali (SSR). I luoghi “classici” in cui viene effettuata la procedura/prestazione vaccinale sono i servizi di vaccinazione della Aziende Sanitarie Locali (ASL) o Provinciali (ASP) delle varie Regioni.

Trehalose-induced local distorsions in iron proteins

The coupling between electron transfer and protein dynamics in the bacterial photosynthetic reaction center: trapping of conformational substates in room temperature amorphous matrices

The photosynthetic reaction center (RC) from purple bacteria is becoming a prototype in exploring the coupling between internal protein motions and long-range electron transfer (ET). This interplay has been extensively investigated by hampering RC substate interconversion and relaxations at low temperatures (McMahon et al., 1998, Biophys. J. 74, 2567). As a complementary approach for limiting RC dynamics at room temperature we embedded the protein within a dehydrated trehalose matrix. Spectroscopic studies and molecular dynamics simulations performed on myoglobin/trehalose/water systems have shown that the nonharmonic contributions to the protein motions (attributed to thermal fluctuations …