0000000000676044

AUTHOR

Irene Dechant

showing 2 related works from this author

Synthesis of bis(indolylmaleimide) macrocycles

2000

The synthesis of a novel class of macrocyclic bis(indolylmaleimides) is reported. The key step involves the intermolecular connection of 2,2′-bridged indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione (dibromomaleimide) derivatives. The bis(indolylmaleimides) afforded by this method were further processed by intramolecular nucleophilic substitution of the remaining bromo substituents forming flexible N-substituted macrocycles (9a-9j, 10a-10e) and, by connecting both maleimides, semi rigid macrocycles (7a-7xx).

Bis-indolylmaleimideChemistryIntramolecular forceOrganic ChemistryIntermolecular forceNucleophilic substitutionMedicinal chemistryJournal of Heterocyclic Chemistry
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ChemInform Abstract: Synthesis of Bis(indolylmaleimide) Macrocycles

2000

The synthesis of a novel class of macrocyclic bis(indolylmaleimides) is reported. The key step involves the intermolecular connection of 2,2′-bridged indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione (dibromomaleimide) derivatives. The bis(indolylmaleimides) afforded by this method were further processed by intramolecular nucleophilic substitution of the remaining bromo substituents forming flexible N-substituted macrocycles (9a-9j, 10a-10e) and, by connecting both maleimides, semi rigid macrocycles (7a-7xx).

Bis-indolylmaleimideChemistryIntramolecular forceIntermolecular forcePolymer chemistryNucleophilic substitutionGeneral MedicineChemInform
researchProduct