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RESEARCH PRODUCT
ChemInform Abstract: Synthesis of Bis(indolylmaleimide) Macrocycles
Alfred PoppIrene DechantSiavosh MahboobiHerwig PongratzDieter SchollmeyerHans Reindlsubject
Bis-indolylmaleimideChemistryIntramolecular forceIntermolecular forcePolymer chemistryNucleophilic substitutionGeneral Medicinedescription
The synthesis of a novel class of macrocyclic bis(indolylmaleimides) is reported. The key step involves the intermolecular connection of 2,2′-bridged indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione (dibromomaleimide) derivatives. The bis(indolylmaleimides) afforded by this method were further processed by intramolecular nucleophilic substitution of the remaining bromo substituents forming flexible N-substituted macrocycles (9a-9j, 10a-10e) and, by connecting both maleimides, semi rigid macrocycles (7a-7xx).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-09-19 | ChemInform |