0000000000676630

AUTHOR

Hannu Alho

showing 2 related works from this author

Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe

2018

All-oral direct-acting antiviral drugs (DAAs) for hepatitis C virus, which have response rates of 95% or more, represent a major clinical advance. However, the high list price of DAAs has led many governments to restrict their reimbursement. We reviewed the availability of, and national criteria for, interferon-free DAA reimbursement among countries in the European Union and European Economic Area, and Switzerland. Reimbursement documentation was reviewed between Nov 18, 2016, and Aug 1, 2017. Primary outcomes were fibrosis stage, drug or alcohol use, prescriber type, and HIV co-infection restrictions. Among the 35 European countries and jurisdictions included, the most commonly reimbursed …

hepatitis C virusHIV Infectionschemistry.chemical_compound0302 clinical medicineAntiviral Agents/economicsHIV-HCV co-infection030212 general & internal medicineReimbursementliver fibrosismedia_commonDasabuvirCoinfectionHealth PolicyGastroenterologyHepatitis C3. Good healthEuropeHepatitis C Chronic/complicationsInsurance Health Reimbursement030211 gastroenterology & hepatologySwitzerlandmedicine.drugmedicine.medical_specialtyHIV Infections/complicationsAntiviral AgentsDrug Costs03 medical and health scienceshepatitis C treatmentmedicineHumansmedia_common.cataloged_instanceEuropean UnionEuropean unionPWIDIntensive care medicineHepatitisdirect-acting antiviralHepatologybusiness.industryHepatitis C Chronicalcohol usemedicine.diseasereimbursementVirologyOmbitasvirchemistryParitaprevirRitonavirbusinesstreatment restrictionsThe Lancet Gastroenterology & Hepatology
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Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats.

1999

Furosemide increases the basal tert-[35S]butylbicyclophosphorothionate ([35S]TBPS) binding and reverses the inhibition of the binding by gamma-aminobutyric acid (GABA) in the cerebellar GABA(A) receptors containing the alpha6 and beta2/beta3 subunits. These effects are less pronounced in the alcohol-sensitive (ANT) than in the alcohol-insensitive (AT) rat line. The difference between the rat lines in the increase of basal [35S]TBPS binding was removed after a longer preincubation with ethylendiaminetetraacetic acid (EDTA) containing buffer, but long preincubation did not reduce the GABA content of the incubation fluid or remove the difference in GABA antagonism by furosemide. The GABA sensi…

Malemedicine.medical_specialtyCerebellumAzidesHealth (social science)BiologySodium ChlorideToxicologyBicucullineLigandsBiochemistryGABA AntagonistsBehavioral Neurosciencechemistry.chemical_compoundBenzodiazepinesFurosemideDMCMInternal medicineCerebellummedicineAnimalsReceptorGABA AgonistsEthanolGABAA receptorFurosemideGeneral MedicineBridged Bicyclo Compounds HeterocyclicReceptors GABA-AANTRatsPyridazinesAlcoholismDrug Combinationsmedicine.anatomical_structureEndocrinologyNeurologyMechanism of actionchemistryFemalemedicine.symptommedicine.drugCarbolinesAlcohol (Fayetteville, N.Y.)
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