Additional file 1: of Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion
Figure S1. a Schematic of the endogenous zebrafish atp13a2 ortholog. The exons are shown are rectangles and the introns as horizontal lines. The splice junctions targeted with antisense morpholino oligonucleotides (atp13a2_3x4_SB and atp13a2_3x6_SB) are shown with red asterisks. b Gel images showing the efficiency of the atp13a2_3x4_SB and atp13a2_3x6_SB morpholinos. The first lane in each gel photograph shows amplicons from the respective loci flanking the targeted sequences, with no aberrations observed. In the embryos injected with morpholino oligonucleotides, aberrant bands were evident, showing that the morpholinos were efficient in knocking down the expression of endogenous atp13a2. F…