0000000000677438
AUTHOR
G. Cangemi
Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis
SUMMARY In this study we have evaluated the modifications of matrix metalloproteinases (MMPs) in malignant pleural fluids taken from patients suffering from lung cancer and treated with intrapleural talc instillation to induce pleurodesis. Furthermore, we have analysed the variations of some inflammatory mediators (C-reactive protein, α-1 antitrypsin) and of a protein (plasminogen) involved in MMP activation. In all patients the clinical improvement after talc pleurodesis was followed by a reduction in MMP-1, TIMP-1, C-reactive protein, α-1 antitrypsin and plasminogen activity. Furthermore, MMP-9 levels were variable; in fact, in some patients they were high at the beginning of treatment, i…
CALR MUTATIONS IN SICILIAN ESSENTIAL THROMBOCYTHEMIA AND MYELOFIBROSIS PATIENTS.
Background. Essential thrombocythemia (ET) and primary myelofibrosis (MF) are myeloproliferative neoplasms characterized by the overproduction of mature cells such as platelets (ET) or early bone marrow fibrosis due to scarring induced by highly proliferating myeloid progenitors and pathological stimulation of local fibroblasts (MF). Somatic mutations in CALR gene have recently identified in the majority of JAK2-V617F and MPL negative ET and MF patients. In this study we evaluated the frequency and type of CALR mutations and their clinical and hematological features. Methods. A total of 54 patients, 29 ET and 25 MF patient, was included in this study. All patients were JAK2 V617F and MPL ne…
Characterization of the Magnetic Induction Field produced by Secondary Substations
The aim of this paper is to develop a methodology for measuring the magnetic field distribution around the prefabricated secondary substations in vibrated reinforced concrete, as well as the definition of a methodology to determining the maximum value of magnetic induction produced by the substations in correspondence to nominal current of the transformer. As proposed has been developed in conformity with laws and standards and can be applied to active and passive secondary substations. The experimental validation of the proposed methodology, carried out by a measurements campaign whose results are reported, confirms the validity and returns a versatile and simple tool for the verification …