0000000000677568

AUTHOR

Marvin Kischkewitz

showing 2 related works from this author

Addition of Nucleophiles to Fluorinated Michael Acceptors

2016

A series of nucleophiles, including primary and secondary amines, primary alcohols, and thiols, as well as diethyl malonate and nitromethane, were added to different fluorinated Michael acceptors including 2-fluoroalk-1-en-3-ones and 2-fluoro-1-phenylprop-2-en-1-one. The resulting beta-substituted afluoro ketones were isolated in 34-92 % yield, depending on the substrate and the nucleophile. The best yields were obtained with secondary amines and with p-methylthiophenol.

Nucleophilic additionPrimary (chemistry)Nitromethane010405 organic chemistryOrganic Chemistrychemistry.chemical_elementEnonesFluorine010402 general chemistry01 natural sciences0104 chemical sciencesDiethyl malonatechemistry.chemical_compoundchemistryNucleophileYield (chemistry)Michael additionFluorineMichael reactionOrganic chemistryPhysical and Theoretical ChemistryNucleophilic addition
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ChemInform Abstract: Addition of Nucleophiles to Fluorinated Michael Acceptors.

2016

A series of nucleophiles, including primary and secondary amines, primary alcohols, and thiols, as well as diethyl malonate and nitromethane, were added to different fluorinated Michael acceptors including 2-fluoroalk-1-en-3-ones and 2-fluoro-1-phenylprop-2-en-1-one. The resulting β-substituted α-fluoro ketones were isolated in 34–92 % yield, depending on the substrate and the nucleophile. The best yields were obtained with secondary amines and with p-methylthiophenol.

chemistry.chemical_compoundPrimary (chemistry)chemistryNitromethaneNucleophileYield (chemistry)Substrate (chemistry)General MedicineMedicinal chemistryDiethyl malonateChemInform
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