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RESEARCH PRODUCT
ChemInform Abstract: Addition of Nucleophiles to Fluorinated Michael Acceptors.
Andreas LerchenDaniel C. RambMarvin KischkewitzBernd BeutelSantos FusteroGünter Haufesubject
chemistry.chemical_compoundPrimary (chemistry)chemistryNitromethaneNucleophileYield (chemistry)Substrate (chemistry)General MedicineMedicinal chemistryDiethyl malonatedescription
A series of nucleophiles, including primary and secondary amines, primary alcohols, and thiols, as well as diethyl malonate and nitromethane, were added to different fluorinated Michael acceptors including 2-fluoroalk-1-en-3-ones and 2-fluoro-1-phenylprop-2-en-1-one. The resulting β-substituted α-fluoro ketones were isolated in 34–92 % yield, depending on the substrate and the nucleophile. The best yields were obtained with secondary amines and with p-methylthiophenol.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 | ChemInform |