0000000000677661

AUTHOR

Alessandro Tagger

showing 2 related works from this author

Can the serological status of anti-HBc alone be considered a sentinel marker for detection of occult HBV infection?

2008

Some individuals have “occult” infection with hepatitis B virus (HBV), defined as presence of HBV genome in the serum or liver tissue without HBV surface antigen (HBsAg) in the serum. The aim of this study was to investigate whether serum antibodies against HBV core antigen in isolation (“anti-HBc alone”) are a useful marker of “occult” HBV in patients with or without hepatitis C virus (HCV) infection. “Anti-HBc alone” was detected in the sera of 119/6,544 (1.8%) asymptomatic outpatients referred to the diagnostic laboratory for routine testing for viral hepatitis, 62/607 (10.2%) drug users, and 42/195 (21.5%) patients with hepatocellular carcinoma. Using three in-house nested-PCR amplifica…

AdultMaleHBV serologic markerHBsAgHepatitis B virusGenotypeHepatitis C virusHBV genotypemedicine.disease_causeSettore MED/42 - Igiene Generale E ApplicataPolymerase Chain ReactionSensitivity and Specificity‘‘occult’’ HBVSerologyOrthohepadnavirusVirologymedicinePrevalenceHumansSerologic TestsHCCAgedHepatitis B virusAged 80 and overbiologybusiness.industryvirus diseasesSequence Analysis DNAHepatitis C AntibodiesMiddle Agedbiology.organism_classificationmedicine.diseaseHepatitis BVirologyHepatitis B Core AntigensHepatitis Cdigestive system diseasesInfectious DiseasesHepadnaviridaeImmunologyDNA Viralanti-HBcFemaleViral diseasebusinessViral hepatitisSentinel Surveillance
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Hepatitis C virus genotypes: distribution and clinical significance in patients with cirrhosis type C seen at tertiary referral centres in Europe

2001

The aim of this study was to evaluate the distribution and clinical significance of hepatitis C virus (HCV) genotypes in European patients with compensated cirrhosis due to hepatitis C (Child class A) seen at tertiary referral centres. HCV genotypes were determined by genotype-specific primer PCR in 255 stored serum samples obtained from cirrhotics followed for a median period of 7 years. Inclusion criteria were biopsy-proven cirrhosis, absence of complications of cirrhosis and exclusion of all other potential causes of chronic liver disease. The proportion of patients with types 1b, 2, 3a, 1a, 4 and 5 were 69%, 19%, 6%, 5%, 0.5% and 0.5%, respectively. Kaplan-Meier 5-year risk of hepatocel…

AdultLiver CirrhosisMalemedicine.medical_specialtyPathologyCirrhosisHepacivirusHepatitis C virusHepacivirusAntibodies ViralChronic liver diseasemedicine.disease_causeAntiviral AgentsGastroenterologyDisease-Free SurvivalStatistics NonparametricSex FactorsSDG 3 - Good Health and Well-beingVirologyInternal medicineHumansMedicineDecompensationLongitudinal StudiesAgedProportional Hazards ModelsHepatologybiologybusiness.industryAge FactorsInterferon-alphaTransfusion ReactionHepatitis CMiddle Agedmedicine.diseasebiology.organism_classificationHepatitis CEuropeTreatment OutcomeInfectious DiseasesRelative riskHepatocellular carcinomaRNA ViralFemalebusiness
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