Update on new approaches in the management of hepatocellular carcinoma

Giuseppe Cabibbo1,2, Michela Antonucci3, Chiara Genco11Sezione di Gastroenterologia, Di.Bi.Mi.S., University of Palermo, Italy; 2Dipartimento di Biopatologia e Metodologie Biomediche, University of Palermo, Italy; 3Department of Oncology, Division of General and Oncological Surgery, University of Palermo, ItalyAbstract: Hepatocellular carcinoma (HCC) is a major health problem. It is currently the third cause of cancer-related death, it is highly prevalent in the Asia–Pacific region and Africa, and is increasing in Western countries. The natural history of HCC is very heterogeneous and prediction of survival in individual patients is not satisfactory because of the wide spectrum of…