0000000000682011
AUTHOR
R. Ferri
TRACE and RELAP5 Codes for Beyond Design Accident Condition Simulation in the SPES3 Facility
Code validation on qualified experimental data is a fundamental issue in the design and safety analyses of nuclear power plants. The SPES3 facility is being built at the SIET laboratories for an integral type SMR simulation, in the frame of an R&D program on nuclear fission, funded by the Italian Ministry of Economic Development and led by ENEA. The facility, based on the IRIS reactor design, reproduces the primary, secondary and containment systems with 1:100 volume scale, full elevation and prototypical fluid and thermal-hydraulic conditions. It is suitable to test the plant response to design and beyond design accidents in order to verify the effectiveness of the primary and containm…
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…