The changing scenario of hepatocellular carcinoma in Italy: an update

Background and aims: Epidemiology of hepatocellular carcinoma (HCC) is changing in most areas of the world. This study aimed at updating the changing scenario of aetiology, clinical presentation, management and prognosis of HCC in Italy during the last 15 years. Methods: Retrospective analysis of the Italian Liver Cancer (ITA.LI.CA) database included 6034 HCC patients managed in 23 centres from 2004 to 2018. Patients were divided into three groups according to the date of cancer diagnosis (2004-2008, 2009-2013 and 2014-2018). Results: The main results were: (i) a progressive patient ageing; (ii) a progressive increase of non-viral cases and, particularly, of ‘metabolic’ and ‘metabolic + alc…

Valutazioni ortognatodontiche nei suonatori di strumenti a fiato

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial

Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…

Risvolti gnato-posturali della sindrome di Rett. Caso clinico

Video projection mapping e arti performative. Una nuova macchina scenotecnica della visione per generare nuovi spazi aumentati

L’oggetto principale della dissertazione è il video projection mapping, un’applicazione di realtà aumentata che utilizza le tecniche di videoproiezione digitale non su tradizionali schermi di proiezione ma sulla realtà stessa, sugli oggetti fisici, ai quali si adatta e si lega in maniera inestricabile, ibridando il livello fisico-reale e il livello digitale. Al contrario di come spesso è stato considerato, il video projection mapping non è solo un gadget tecnologico dei nostri tempi; quando si ibrida con altri media, come le arti performative, diviene linguaggio metaforico, oltrepassando il suo livello tecnologico per produrre significati, per mediare idee. Considerando il suo uso nello spe…

Pattern of macrovascular invasion in hepatocellular carcinoma

Background and aims: In patients with hepatocellular carcinoma (HCC), macrovascular invasion (MaVI) limits treatment options and decreases survival. Detailed data on the relationship between MaVI extension and patients' characteristics, and its impact on patients' outcome are limited. We evaluated the prevalence and extension of MaVI in a large cohort of consecutive HCC patients, analysing its association with liver disease and tumour characteristics, as well as with treatments performed and patients' survival. Methods: We analysed data of 4774 patients diagnosed with HCC recorded in the Italian Liver Cancer (ITA.LI.CA) database (2008-2018). Recursive partition analysis (RPA) was performed …