0000000000682465

AUTHOR

Mario Zoratti

showing 2 related works from this author

Mitochondrial genetic haplogroups and depressive symptoms: A large study among people in North America.

2017

Background:\ud A possible relationship between mitochondrial haplogroups and psychiatric diseases (e.g. schizophrenia and bipolar disorder) has been postulated, but data regarding depression is still limited. We investigated whether any mitochondrial haplogroup carried a significant higher risk of depressive symptoms in a large prospective cohort of North American people included in the Osteoarthritis Initiative.\ud \ud Methods:\ud Cross sectional data was derived from the Osteoarthritis Initiative. The haplogroup was assigned through a combination of sequencing and PCR-RFLP techniques. All the mitochondrial haplogroups were named following this nomenclature: H, U, K, J, T, V, SuperHV, I, W…

0301 basic medicineMalemitochondrial haplogroupsCross-sectional studyHaplogroup H*Osteoarthritis initiativePopulation*Mitochondrial haplogroupsDNA MitochondrialHaplogroupArticleWhite People03 medical and health sciences0302 clinical medicineMedicineHumansGenetic Predisposition to DiseaseBipolar disorderProspective Studieseducationeducation.field_of_studybusiness.industryDepressionHaplotypeOsteoarthritis initiativeMiddle Agedmedicine.disease*Depressionhumanities3. Good healthDepression; Mitochondrial haplogroups; Osteoarthritis initiative; Clinical Psychology; Psychiatry and Mental HealthClinical PsychologyMitochondrial haplogroups Depression Osteoarthritis initiative030104 developmental biologyMoodCross-Sectional StudiesHaplotypesPsychiatry and Mental HealthNorth AmericadepressionMitochondrial haplogroupsFemalebusinessosteoarthritis initiative030217 neurology & neurosurgeryHuman mitochondrial DNA haplogroupDemographyClinical psychology
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The Vibrio choleare haemolysin anion channel is required for cell vacuolation and death

2002

SummarySeveral strains of Vibrio cholerae secrete ahaemolytic toxin of 63kDa, termed V. cholerae cytolysin (VCC). This toxin causes extensive vacuo-lation and death of cells in culture and forms ananion-selective channel in planar lipid bilayers and incells. Here, we identify inhibitors of the VCC anionchannel and show that the formation of the anionchannel is necessary for the development of the vacuoles and for the cell death induced by this toxin. Using markers of cell organelles, we show that vacuoles derive from different intracellular com-partments and we identify the contribution of lateendosomes and of the trans -Golgi network in vacuolebiogenesis.Introduction The Gram-negative bact…

4-Acetamido-4'-isothiocyanatostilbene-22'-disulfonic AcidImmunologyLipid BilayersVirulenceGolgi ApparatusVacuoleEndosomesBiology44'-Diisothiocyanostilbene-22'-Disulfonic AcidIn Vitro Techniquesmedicine.disease_causeTransfectionMicrobiologyModels BiologicalAmmonium ChlorideIon ChannelsMicrobiologyCell LineHemolysin ProteinsBacterial ProteinsVirologyOrganelleChlorocebus aethiopsmedicineAnimalsHumansSecretionVero CellsVibrio choleraeCell DeathCytotoxinsHemolysinAnti-Bacterial AgentsVibrio choleraeVacuolesCytolysinMacrolidesIntracellular
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