0000000000682621
AUTHOR
M. Herrmann
Consensus guidelines for the detection of immunogenic cell death
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defect…
Nachweis der Mehrfachemission von Sekund�relektronen mittels Proportionalz�hlrohr
A proportional counter is used as analyser for electron energies (in the range 10 to 20 keV). The resolving power for 20 keV is 21%. The multiple emission of secondary electrons is investigated with this counter.