0000000000682795
AUTHOR
Richard A. Young
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification of effective pharmacological strategies to target SCLC biology represents an urgent need. Using a high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to transcription-targeting drugs, in particular to THZ1, a recently identified covalent inhibitor of cyclin-dependent kinase 7. We find that expression of super-enhancer-associated transcription factor genes, including MYC family proto-oncogenes and neuroendocrine lineage-specific factors, is highly vulnerability to THZ1 treatment. We propose that downregulation of these transcription factors contribut…
Using Contextual Action Theory for conceptualization and research on adolescent development
Recently, scholars’ calls for psychology to move beyond traditional ways of conceptualizing and researching human behaviour have increased. Contextual Action Theory (CAT) is a conceptual, methodological, and practical framework that is consistent with these calls. In CAT action is conceptualized as a complex, dynamic, and multidimensional system that can be comprehended from multiple levels of organization and from multiple perspectives. The Action-Project Method (A-PM) is the research method that emerged from CAT. It is a qualitative, naturalistic, process-oriented, longitudinal methodology that has been used to study joint, goal-directed actions and projects. The focus of data gathering a…