0000000000682857

AUTHOR

Immacolata Greco

showing 2 related works from this author

USE OF FUZZY NEURAL NETWORKS IN MODELING RELATIONSHIPS OF HPV INFECTION WITH APOPTOTIC AND PROLIFERATION MARKERS IN POTENTIALLY MALIGNANT ORAL LESIONS

2005

To evaluate in oral leukoplakia the relationship between HPV infection and markers of apoptosis (bcl-2, survivin) and proliferation (PCNA), also conditionally to age, gender, smoking and drinking habits of patients, by means of Fuzzy neural networks (FNN) system 21 cases of oral leukopakia, clinically and histologically diagnosed, were examined for HPV DNA presence, bcl-2, survivin and PCNA expression. HPV DNA was investigated in exfoliated oral mucosa cells by nested PCR (nPCR: MY09-MY11/GP5-GP6), and the HPV genotype determined by direct DNA sequencing. All markers were investigated by means of standardised immunohistochemistry procedure. Data were analysed by chi-square test, crude OR an…

MaleCancer ResearchOral precancerous lesionSurvivinFuzzy neural networksApoptosisPolymerase Chain ReactionInhibitor of Apoptosis Proteinslaw.inventionlawGenotypePapillomaviridaePolymerase chain reactionLeukoplakiabiologySmokingHPV infectionvirus diseasesMiddle Agedfemale genital diseases and pregnancy complicationsNeoplasm ProteinsCell Transformation NeoplasticProto-Oncogene Proteins c-bcl-2OncologyCarcinoma Squamous CellFemaleMouth NeoplasmsLeukoplakia OralOral SurgeryMicrotubule-Associated ProteinsAdultHPVFuzzy LogicProliferating Cell Nuclear AntigenSurvivinCarcinomamedicineHumansBcl-2AgedCell ProliferationAnalysis of VariancePapillomavirus InfectionsMouth Mucosamedicine.diseaseProliferating cell nuclear antigenDNA ViralImmunologybiology.proteinCancer researchNeural Networks ComputerNested polymerase chain reaction
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HPV DNA and survivin expression in epithelial oral carcinogenesis: a relationship?

2004

Abstract HPV has been thought to be involved in the development of several oral diseases, such as premalignant mucosal lesions and oral carcinoma. Survivin is a recently characterized IAP protein, which is abundantly expressed in most solid and haematological malignancies, but undetectable in normal adult tissues. Aim of this study was to investigate survivin expression and HPV presence in oral premalignant lesions and oral carcinoma. 47 samples of oral tissue including 11 squamous cell carcinomas (OSCC), 16 oral leukoplakias (OL) and 20 normal oral mucosa specimens, after investigation of HPV presence by nested PCR (consensus MY/GP primers) and viral genotype identification by direct seque…

MaleCancer ResearchPathologymedicine.medical_specialtySurvivinCellBiologymedicine.disease_causeInhibitor of Apoptosis ProteinsSurvivinmedicineCarcinomaHumansPapillomaviridaeHPV infectionvirus diseasesCell Transformation Viralmedicine.diseasefemale genital diseases and pregnancy complicationsEpitheliumNeoplasm Proteinsstomatognathic diseasesCell Transformation Neoplasticmedicine.anatomical_structureOncologyEpidermoid carcinomaDNA ViralCarcinoma Squamous CellCancer researchImmunohistochemistryFemaleMouth NeoplasmsLeukoplakia OralOral SurgeryCarcinogenesisMicrotubule-Associated ProteinsPrecancerous ConditionsOral Oncology
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