0000000000684292
AUTHOR
Michael H. Abraham
Analysis of a solute polarity parameter in reversed-phase liquid chromatography on a linear solvation relationship basis
Abstract A study was made to correlate an overall solute polarity descriptor ( p ) with several molecular parameters: excess molar refraction ( E ), dipolarity/polarizability ( S ), effective hydrogen-bond acidity ( A ) and basicity ( B ), and McGowan volume ( V ), through the linear solvation model ( p = c + eE + sS + aA + bB + vV ). The achieved values of p were introduced in a retention model developed previously for reversed-phase liquid chromatography (RPLC), which describes the retention according to the polarity contributions of solute, mobile phase and stationary phase. The retention behaviour (log k ) of a solute in a given chromatographic system (i.e. column/organic solvent) is a…
Micellar versus hydro-organic reversed-phase liquid chromatography: a solvation parameter-based perspective.
The performance of the solvation parameter model is examined for micellar liquid chromatography. The results are compared with those offered with hydro-organic eluents, intending to reveal the properties that influence the retention and distinguish the particular behaviour of micellar systems. The retention data of several series of non-ionisable and ionisable compounds (mainly steroids, polyaromatic hydrocarbons, phenols, sulfonamides, beta-blockers, phenethylamines, antihistamines, and diuretics) were used as probe compounds. The micellar mobile phases contained an anionic (sodium dodecyl sulphate), non-ionic (Brij-35), or cationic (cetyltrimethylamonium bromide) surfactant, with or witho…