0000000000697033
AUTHOR
Kay Nolte
Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy
Objective: To analyze antisynthetase syndrome–associated myositis by modern myopathologic methods and to define its place in the spectrum of idiopathic inflammatory myopathies (IIMs). Methods: Skeletal muscle biopsies from antisynthetase syndrome–associated myositis and other IIMs from different institutions worldwide were analyzed by histopathology, quantitative PCR, and electron microscopy. Results: Myonuclear actin filament inclusions were identified as a unique morphologic hallmark of antisynthetase syndrome–associated myositis. Nuclear actin inclusions were never found in dermatomyositis, polymyositis, sporadic inclusion body myositis, autoimmune necrotizing myopathy associated with si…
Long Term Outcome after Application of the Angio-Seal Vascular Closure Device in Minipigs
PLoS one 11(9), e0163878 (2016). doi:10.1371/journal.pone.0163878