BRCA1 missense variants of uncertain clinical significance in unaffected and breast/ovarian cancer of the Sicilian population.

Q356R and S1512I are BRCA1 variants that may be associated with breast cancer in a Sicilian family.

Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit

Contains fulltext : 177598.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance. For this analysis, we included only the 1,808 patients with an admission diagnosis of sepsis. Patients were stratified according to quartiles of cumulative f…