Intraperitoneal Application of Fibrinogen Gluing in the Rat for Adhesions Prophylaxis

The suitability of fibrinogen gluing for prophylaxis of intraperitoneal adhesions was investigated experimentally. Small bowel slings, traumatized previously, were covered by a layer of fibrinogen 2–3 mm thick to see whether formation of adhesions could be prevented. In the experiments 50 rats of both sexes were observed over 21 days. Following mechanical traumatization of the terminal ileum the visceral peritoneum was coated with fibronogen, whereas animals of the control group did not receive fibrinogen coating.