0000000000699794

AUTHOR

C. Juan

showing 3 related works from this author

Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility

2013

In the last four years, Genome-Wide Association Studies (GWAS) have identified sixteen low-penetrance polymorphisms on fourteen different loci associated with colorectal cancer (CRC). Due to the low risks conferred by known common variants, most of the 35% broad-sense heritability estimated by twin studies remains unexplained. Recently our group performed a case-control study for eight Single Nucleotide Polymorphisms (SNPs) in 4 CRC genes. The present investigation is a followup of that study. We have genotyped six SNPs that showed a positive association and carried out a meta-analysis based on eight additional studies comprising in total more than 8000 cases and 6000 controls. The estimate…

Linkage disequilibriumGenotypeReparació de l'ADNlcsh:MedicineDNA repairGenome-wide association studySingle-nucleotide polymorphismBiologyGenetic polymorphismsDNA Mismatch RepairPolymorphism Single NucleotideDNA Glycosylases03 medical and health sciences0302 clinical medicineMUTYHCàncer colorectalHumansGenetic Predisposition to Diseaselcsh:ScienceGenetic Association Studies030304 developmental biologyGenetic associationGenetics0303 health sciencesMultidisciplinaryGenetic heterogeneityPolimorfisme genèticlcsh:RCase-control studyOdds ratioColorectal cancer3. Good health030220 oncology & carcinogenesisCase-Control Studieslcsh:QColorectal NeoplasmsResearch Article
researchProduct

Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of beta-agonists in animal feed and drinking w…

2010

A reproducible, sensitive and selective multiresidue analytical method for seven beta-agonists: clenbuterol (CBT), clenpenterol (CPT), ractopamine (RTP), brombuterol (BBT), mabuterol (MBT), mapenterol (MPT), and hydroxymethylclenbuterol (HMCBT) was developed and validated by using liquid chromatography tandem mass spectrometry (LC-MS/MS) in feed and drinking water samples. The validation was achieved according to the criteria laid down in the Commission Decision 2002/657/EC, however it was necessary to use minimum required performance limits (MRPLs) proposed by the Community Reference Laboratories (CRLs) due to the lack of maximum residue limits (MRLs) for beta-agonists. By setting up these…

Animal feedBiochemistryHigh-performance liquid chromatographySensitivity and SpecificityAnalytical Chemistrychemistry.chemical_compoundLiquid chromatography–mass spectrometryTandem Mass SpectrometryWater SupplyPhenethylaminesSample preparationResidue (complex analysis)ChromatographyMabuterolOrganic ChemistryReproducibility of ResultsWaterGeneral MedicineAdrenergic beta-AgonistsAnimal FeedRactopaminechemistryEthanolaminesLinear ModelsWater qualityChromatography LiquidJournal of chromatography. A
researchProduct

A Prospective Audit of the Complications of Loop Ileostomy Construction and Takedown

2004

<i>Aim:</i> A prospective review of the complications of ileostomy construction and takedown. <i>Materials and Methods:</i> One hundred twenty-seven consecutive patients undergoing construction of a loop ileostomy were included in a prospective nonrandomized computer database. Complications of the loop ileostomy were assessed prior to and after closure. Three closure techniques were performed [enterotomy suture (25.7%), resection and hand sewn (31.2%) or stapled anastomosis (43.1%)] and compared. <i>Results:</i> One hundred twenty-seven (73 male, 54 female) patients, mean age 54 years were included from 1992 to 2002. Seventy-two patients underwent anterio…

Malemedicine.medical_specialtyIleostomyRectal Neoplasmsbusiness.industryProspective auditLoop ileostomymedicine.medical_treatmentGeneral surgeryGastroenterologyColonic PouchesMiddle AgedSurgeryIleostomymedicineHumansFemaleSurgeryProspective StudiesProspective cohort studybusinessDigestive Surgery
researchProduct