0000000000699818
AUTHOR
N. David
showing 2 related works from this author
Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility
2013
In the last four years, Genome-Wide Association Studies (GWAS) have identified sixteen low-penetrance polymorphisms on fourteen different loci associated with colorectal cancer (CRC). Due to the low risks conferred by known common variants, most of the 35% broad-sense heritability estimated by twin studies remains unexplained. Recently our group performed a case-control study for eight Single Nucleotide Polymorphisms (SNPs) in 4 CRC genes. The present investigation is a followup of that study. We have genotyped six SNPs that showed a positive association and carried out a meta-analysis based on eight additional studies comprising in total more than 8000 cases and 6000 controls. The estimate…
CERN’s Linac4 cesiated surface H− source
2017
Linac4 cesiated surface H− sources are routinely operated for the commissioning of the CERN’s Linac4 and on an ion source test stand. Stable current of 40-50 mA are achieved but the transmission through the LEBT of 80% was below expectations and triggered additional beam simulation and characterization. The H− beam profile is not Gaussian and emittance measurements are larger than simulation. The status of ongoing development work is described; 36 mA H− and 20 mA D− beams were produced with a 5.5 mm aperture cesiated surface ion source. The emittances measured at the test stand are presented. During a preliminary test, the Linac4 proton source delivered a total beam intensity of 70 mA (p, H…