Transport of amino acids and their phosphonic acid analogues through supported liquid membranes containing macrocyclic carriers. Experimental parameters

Abstract Amino acid hydrochlorides are well transported through 1-decanol membranes containing Kryptofix 5 or 222 and supported in a porous polyacrylonitrile hollow fiber matrix. Factors which influence the transport of phenylalanine hydrochloride were studied in some detail using this sheet- as well as hollow fibre-supported liquid membranes. These studies show that the choice of the membrane phase, the kind of polymeric support and the mode of membrane preparation are of great importance for the efficiency of the process. The most vital step in the membrane preparation appears to be its activation by soaking in a solution of phenylalanine hydrochloride in a water-ethanol or water-propanol…

Crown-ether mediated transport of amino acids through an immobilized liquid membrane

Enantioselective transport of amino acid through supported chiral liquid membranes

Abstract Two chiral alcohols, nopol and (2S)-(−)-methyl-1-butanol, immobilized in the pores of a polyethylene film were used for the anantioselective transport of amino acid hydrochloride. The degree of stereoselectivity of the permeation process varied from 0.39 to 1.52 depending on both the type of the chiral membrane phase and the properties of the amino acid. The evaluation of the membrane ability to separate stereoisomers was performed by the step-by-step analysis by considering the effect of amino acids' hydrophobicity, polarity and degree of chirality. For the purpose of this paper, the chirality measure was introduced. It was demonstrated that the enantioselectivity was affected mai…

Transport of dipeptides and phosphono dipeptides through an immobilized liquid membrane. Stereoselectivity of the process

Abstract Dipeptide and phosphono dipeptide hydrochlorides permeated well through a 1-decanol membrane supported in a porous polyethylene hollow fiber matrix. This transfer is easily accomplished either by passive or by carrier-facilitated (with Kryptofixes 222 or 5 present in the membrane phase) transport. The transport is stereoselective with l-l dipeptides being transported faster than their l-d isomers.