0000000000701098

AUTHOR

Mauro Rinaldi

0000-0002-7092-8619

showing 3 related works from this author

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

2021

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 da…

Malepulmonary embolismInternationalitySettore MED/18 - CHIRURGIA GENERALEDeep veinVascular damage Radboud Institute for Health Sciences [Radboudumc 16]infectious diseasesCardiovascularSARS‐CoV‐2surgeryCOVID-19 ; SARS-CoV-2 ; deep vein thrombosis ; pulmonary embolism ; venous thromboembolismCohort StudiesPostoperative ComplicationsAnesthesiologyMedicine and Health SciencesProspective Studies610 Medicine & healthProspective cohort studyLung11 Medical and Health SciencesConfoundingHematologyMiddle AgedThrombosis17 Psychology and Cognitive SciencesCOVID-19; deep vein thrombosis; pulmonary embolism; SARS-CoV-2; venous thromboembolismPulmonary embolismCOVID-19; SARS-CoV-2; deep vein thrombosis; pulmonary embolism; venous thromboembolism.medicine.anatomical_structureCohortCOVID-19/complicationsPostoperative Complications/etiologyOriginal ArticleFemalePatient SafetyLife Sciences & BiomedicineCOVID-19; SARS-CoV-2; deep vein thrombosis; pulmonary embolism; venous thromboembolismHumanAdultmedicine.medical_specialtyAdolescentClinical Sciencesvenous thromboembolism610 Medicine & healthGlobalSurg CollaborativeVenous Thromboembolism/etiologydeep vein thrombosisNOCOVIDSurg CollaborativeYoung AdultMedicine General & InternalAge DistributionClinical ResearchCOVID‐19General & Internal MedicinemedicineHumansSex DistributionAgedScience & Technologybusiness.industrySARS-CoV-2PreventionNeurosciencesdeep vein thrombosiCOVID-19PneumoniaOdds ratioOriginal Articlesmedicine.diseaseSurgeryReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Prospective StudieGood Health and Well BeingAnesthesiology and Pain MedicineHuman medicinePostoperative ComplicationCohort StudiebusinessVenous thromboembolism[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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The Neochord Procedure After Failed Surgical Mitral Valve Repair.

2021

Surgical mitral valve reintervention is associated with significant morbidity and mortality, and repeat repair is not always feasible. We examine the clinical outcomes of the NeoChord procedure after failed conventional mitral valve repair. A total of 312 patients were treated with the NeoChord repair procedure between January 2014 and December 2018 at 5 European centers. Clinical and echocardiographic data were reviewed to identify patients who had a prior surgical mitral valve repair procedure. The primary endpoint (Patient Success) was a composite of placement of at least 2 neochordae and end-procedure mitral valve regurgitation (MR) ≤ mild, freedom from death, stroke, structural or func…

Pulmonary and Respiratory MedicineReoperationmedicine.medical_specialtymedicine.medical_treatmentMR recurrence030204 cardiovascular system & hematologylaw.invention03 medical and health sciences0302 clinical medicinelawMitral valvemedicineHumansBeating-heart surgery; MR recurrence; MV repair failure; Neochords; Off-pump mitral valve surgeryAortic dissectionHeart Valve Prosthesis ImplantationMV repair failureMitral valve repairMitral regurgitationEjection fractionBeating-heart surgerybusiness.industryOff-pump mitral valve surgeryMitral Valve InsufficiencyAtrial fibrillationGeneral Medicinemedicine.diseaseIntensive care unitSurgerymedicine.anatomical_structureTreatment OutcomeNeochords030228 respiratory systemEchocardiographyMitral ValveSurgeryCardiology and Cardiovascular MedicineMitral valve regurgitationbusinessSeminars in thoracic and cardiovascular surgery
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Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure.

2009

Increased oxidative stress has been implicated in the pathogenesis of a number of cardiovascular diseases. Recent findings suggest that myeloperoxidase (MPO) may play a key role in the initiation and maintenance of chronic heart failure (CHF) by contributing to the depletion of the intracellular reservoir of nitric oxide (NO). NO consumption through MPO activity may lead to protein chlorination or nitration, leading to tissue damage. Primary cultures of human endocardial endothelial cells (EEC) obtained at heart transplantation of patients with CHF and human umbilical vein endothelial cells (HUVEC) were subjected to oxidative stress by incubation with hydrogen peroxide at non lethal (60 mic…

medicine.medical_specialtyPathologyUmbilical VeinsEndothelium3-chlorotyrosine endocardium endothelial cells myeloperoxidase oxidative stressPhysiologyGene Expressionmedicine.disease_causeUmbilical veinNitric oxidechemistry.chemical_compoundPhysiology (medical)Internal medicinemedicineHumansRNA MessengerCells Cultured3-ChlorotyrosinePeroxidaseHeart FailurebiologyReverse Transcriptase Polymerase Chain ReactionSettore BIO/16 - Anatomia UmanaNitrotyrosineMyocardiumEndothelial CellsHydrogen PeroxideOxidantsImmunohistochemistryEndothelial stem cellOxidative Stressmedicine.anatomical_structureEndocrinologychemistryMyeloperoxidaseChronic Diseasebiology.proteinTyrosineCardiology and Cardiovascular MedicineOxidative stress
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