Author: Octavio Diez

0000000000702117

AUTHOR

Octavio Diez

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Composition influence on pulmonary delivery of rifampicin liposomes.

2012

The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (&#126;100 nm), negatively charged (&#126;60 mV) vesicles were obtained. Lipid composition affected aerosol delivery features of liposomal rifampicin; in particular, the highest phospholipid concentration led to a better packing of the vesic…

liposomesaerosolPhospholipidpulmonary deliveryPharmaceutical Sciencelcsh:RS1-441liposomes; rifampicin; cholesterol; oleic acid; rheology; pulmonary delivery; aerosol; cell viability; cellular uptakerifampicinArticlelcsh:Pharmacy and materia medicachemistry.chemical_compoundPhosphatidylcholineMedicinecell viabilityLiposomeChromatographyCholesterolbusiness.industryVesiclecholesterolcellular uptakeIn vitroOleic acidchemistryBiochemistryoleic acidToxicitylipids (amino acids peptides and proteins)rheologybusinessPharmaceutics

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PEPhysical Sciences and Engineering
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